Process Development and Scale-up

  • Biofuels and Bio-Product Separations, Biomass Fractionation, Lignin Separation, and Fermentation

    ABPDU hosts different centrifugation units including basket centrifuge, Andritz D2L decanter, Alfa Laval MBPX 404 three-phase disc stack centrifuge, and dead-end centrifuge with 6x2L capacity. Andritz D2L decanter allows rapid solid liquid separation with maximum flow rate of 6 m3/h when separating slurries with 1% (w/w) solid. Alfa Laval DSC can be used for S-L, L-L, & S-L-L separations with maximum 150 L/min throughput. Read More

  • Capacitive Deionization (CDI)

    Overview Electrochemical systems for ionic species removal from liquid streams include well-established platforms such as electrodialysis and electrodeionization along with emerging ones such as capacitive deionization (CDI). One advantage of electrochemical separations is the ability to target and remove the minority component (ions) rather than… Read More

  • Chemical and Biological Separations

    Argonne has laboratory and pilot-scale system of various membrane separations that include MF,UF RO and selective membrane separations, ceramic membrane contactor (for liquid-liquid extraction), electrochemical ion-exchange membrane separation, ion-exchange resin wafer membrane separations.  Read More

  • Counter Current Chromatography (CCC)

    Overview CCC is a scalable chromatographic technology that uses the counter current motion of a two-phase liquid-liquid system to generate a chromatographic effect on the solvated compounds, separating them into pure components. It is an emerging technology with recently developed instruments capable of ton /… Read More

  • Distillation

    PNNL has distillation capabilities ranging from systems that can process on the order of 1-liter/day to up 30-gallons/day of material. These capabilities include a laboratory-scale distillation system, a wiped film distillation system, and a skid-mounted distillation system. Read More

  • Dynamic Membranes

    Overview Dynamic membranes operate by moving the membrane rapidly (using vibration or rotation) to generate a shear force at the membrane surface and the feed stream that is being filtered. This is opposed to traditional Tangential Flow Filtration (TFF) that generates a sheer force by… Read More

  • In Situ Product Recovery (ISPR)

    Overview In Situ Product Recovery (ISPR) is a form of process intensification wherein product is separated from a bioreactor as it is produced from the microorganism. ISPR has many process benefits including increased titer, rate, and yield by ameliorating end product inhibition, reducing bioprocess water… Read More

  • Micro-Channel Distillation

    PNNL has unique capabilities in micro-channel-based distillation, with demonstrated heights of a theoretical plate (HETP) of < 3.3 millimeters.  This is nearly two orders of magnitude less than commercial structured packings that report HETP values of 300 to 600 millimeters.  Read More

  • Simulated Moving Bed (SMB) Chromatography and Continuous Ion Exchange (CIX)

    Overview SMB is a scalable chromatographic technology that simulates the counter current motion of the solids stationary phase against the liquid eluent. SMB technology is used today for continuous chromatographic separations at the commodity scale. For example, parrafins are separated from kerosine to produce straight… Read More

  • Ultrasonic Filtration and Particulate Removal

    Low-energy ultrasonic separation is being developed at LANL for broad industrial application. Its fundamental construct is the removal of particles in liquid media. It cuts energy by moving particles a short distance where they meet up with other particles to form large aggregates that settle quickly to effect separation. This construct can be applied to a broad range of industrial applications such as concentrating and dewatering microalgae in seawater, removing fines from bioprocess and mineral streams, and for coalescing emulsion droplets. Read More