In Situ Product Recovery (ISPR)

Overview In Situ Product Recovery (ISPR) is a form of process intensification wherein product is separated from a bioreactor as it is produced from the microorganism. ISPR has many process benefits including increased titer, rate, and yield by ameliorating end product inhibition, reducing bioprocess water footprints and reducing overall separations train energy footprint. Researchers in the Bioprocessing Separations Consortium are advancing ISPR technology by developing systems that can operate in high solids environments, reduce chemical consumption demand, reduce energy demand through novel heat integration strategies.
National Laboratory National Renewable Energy Laboratory (NREL)
Additional Information None
Acids present in bioreactor (1) are extracted into an organic phase through a hollow fiber membrane contactor (2). The bio- reactor media and cells are recycled (3) and the organic phase is passed into a distillation column (4) where neat free acids are vaporized (5) and recovered as a distillate from the heavy organic phase (6).